Howard Florey

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Howard Florey was the first Australian to win the Nobel Prize for Physiology or Medicine. He shared the 145 award with the German refugee chemist Ernst Chain and the Scottish microbiologist Alexander Fleming. Working together at Oxford University, Florey and Chain built a research team that transformed penicillin (discovered by Fleming in 1) from a laboratory curiosity into a widely available drug. Penicillin is one of the most efficient remedies ever discovered, and in the 140s its effects seemed almost miraculous. It revolutionized medicine, allowing once lethal infections, pneumonia, diphtheria, syphilis, meningitis, gas gangrene--to be cured. For infections that were resistant to penicillin, other antibiotics were soon found, including cephalosporin, which was also developed by the Oxford group. Florey was born in Adelaide to a wealthy family. Rather than enter his fathers shoe-making business, he resolved to study medicine, and in 11 won a Rhodes scholarship to Oxford University. In the mid-10s, he became intrigued by the problem of extracting pure penicillin from the Penicillium mold without destroying its potency. He later assembled a multidisciplinary team--including his wife Ethel to work on manufacturing the drug. The technical difficulties of carrying out such a project in wartime Britain were enormous, and at first the team struggled to produce enough penicillin to cure a few infected mice. The amounts available to treat the earliest patients were so limited that the researchers concentrated the drug back from urine, then reinjected it. But (thanks in part to collaboration with well-funded U.S. researchers) by the time of the D-Day landings in 144, penicillin was available in sufficient quantities to save the lives of many wounded Allied and German soldiers. In his approach to practical science, Florey was a true experimentalist, and is credited with establishing the nexus between physiology (normal function) and pathology (disease) that defines the discipline of experimental pathology.

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The Nobel and other accolades gave Florey great influence, which he used well. He visited Australia often, and his efforts were central to the establishment of the Australian National University as a postgraduate research university, a visionary idea for its time. Florey assumed responsibility for the initial phase of the ANUs John Curtin School of Medical Research, contributing greatly to the recruitment of a stellar group of founding professors. Though he continued living in England, he was chancellor of the ANU (making annual trips to Canberra), when he died at age 6 from cardiovascular disease. A typical Australian stoic, he suffered angina in silence for many years. Today, coronary bypass surgery would probably have given him a decade more of productive life.Florey was a familiar figure to Australians of his time, but the 100th anniversary of his birth, in 18, attracted little public interest, even in his home town of Adelaide. When I spoke there at a well-advertised event in his honor, the Crows football team were on a winning streak and the press seemed terminally obsessed with Sir Donald Bradmans 0th birthday. Australia has not, so far, been looked on as a land of opportunity for the intellectual, Florey said in 158. That is changing, but young Australians need to be reminded that their country has produced great achievers in science, the arts and the world of ideas. A sophisticated society can support a broad pantheon of heroes.Peter Doherty and Rolf Zinkernagel won the 16 Nobel Prize for Physiology or Medicine for their work on viral infections and immunity, carried out at the John Curtin School of Medical Research.BORN Sept. 4, 188, in Malvern, Adelaide1 Attends Oxford University on a Rhodes scholarship15 Becomes Professor of Pathology at Oxford14 His department publishes Antibiotics160 Becomes first Australian president of the Royal Society165 Becomes life peer as Baron Florey of Adelaide and MarstonDIED Feb. 1, 168, in OxfordFlorey gathered a team of scientists at Oxford University in Britain in the 10s, when working together on scientific discoveries as a group was not at all common.His team commenced a careful investigation of the properties of anti-bacterial substances that are produced by mould. One member of the team, Ernst Chain, found an article about Alexander Flemings work while flicking through a medical journal, and this prompted them to begin looking at penicillin. Individual members of the group concentrated their attention on areas in which they had the most knowledge, but they often met to exchange ideas. Chain worked on purifying penicillin with Edward Abraham. Norman Heatley improvised methods for extracting penicillin using ether and bedpans (see penicillin production below). A. D. Gardner and Jena Orr-Ewing studied how penicillin reacted with other organisms. Howard Florey looked with Margaret Jennings at the impact of penicillin on animals. Ethel Florey later worked with her husband on clinical trials of penicillin. In May, 140 they performed one of the most important medical experiments in history. The work was so urgent that they came in to begin the experiment on the weekend, and on Saturday 5 May, Floreys team tested penicillin on eight mice injected with a lethal dose of streptococci bacteria. Four of the mice were treated with penicillin, while four were used as controls. By the next day, the treated mice had recovered and the untreated mice were dead. In the early days of World War II, the lives of eight mice may seem insignificant. But their rescue by penicillin led to the treatment of Allied soldiers as early as D-Day, in June 144, and probably influenced the outcome of the war. In 14 Florey travelled to North Africa to test the effects of penicillin on wounded soldiers. His trials were seen as a miracle. Instead of amputating wounded limbs or simply leave them to heal, he suggested soldiers wounds be cleaned and sewn up, and that the patients then be given penicillin. Thanks to Florey and his team, the drug was available to treat Allied troops by the end of World War II. It has since revolutionised medical science, saving millions of lives. Please note that this sample paper on Howard Florey is for your review only. In order to eliminate any of the plagiarism issues, it is highly recommended that you do not use it for you own writing purposes. In case you experience difficulties with writing a well structured and accurately composed paper on Howard Florey, we are here to assist you. Your cheap research papers on Howard Florey will be written from scratch, so you do not have to worry about its originality.

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